Efficacy of collagen-only scaffolds compared to polymer-associated collagen and nanomaterials in skin wound repair – a review

Wound healing remains a clinical problem, with cases of atrophic, hypertrophic, or keloid scars. Three-dimensional scaffolds have been used to restore skin function, facilitating cell migration, adhesion, and proliferation. Collagen is the most common, presenting low antigenicity, decreased inflammation, replacement by autologous tissue. It as sheets/films, sponges, membranes, sprays, hydrogels various origins. This integrative literature review aimed evaluate application unassociated collagen for wound compare them associations nanomaterials polymers. Properties such applications in humans other unconventional models cause burns, partial full-thickness wounds, others. Scaffold, biomaterials, collagen, wound, injury, repair, were among descriptors. We found 3,098 articles published between 1995 2022 (Mendeley platform), including clinical/experimental trials. After exclusion, 26 studies identified analyzed. Autologous heterologous collagens are clinic favor closure improving re-epithelialization reducing inflammation but may present challenges aesthetic acceptance loss repair function site. Furthermore, integration improved experimental models.